Ziprasidone (Azona, Zipsydon)

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Chapter: Medicinal Chemistry : Tranquillizers

Tranquillizers - Ziprasidone (Azona, Zipsydon) - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile

Ziprasidone (Azona, Zipsydon)




Condensation of product of Step II and Step-I

Properties and uses: It exists as a white to faint pink powder, hemihydrate. An atypical antipsychotic, this agent must be given with food twice daily for maximum effect. Adverse effects include somnolence and minor Q TC prolongation. Currently, this is the only atypical antipsychotic available in a parenteral (IM) formulation.

Dose: For Schizophrenia: Adult: As hydrochloride: ≥ 18 years: Initially 20 mg twice a day, increase if necessary at intervals of not less than two days, up to 80 mg twice a day. Maintenance: 20 mg twice a day. Elderly: Lower initial dose with slow titration and close monitoring.

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