Antazoline (Antistine)

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Antihistamines - > H1-antagonists with classical structure - > Antazoline (Antistine) - Synthesis and Drug Profile


SYNTHESIS AND DRUG PROFILE

H1-antagonists with classical structure

Miscellaneous

Antazoline (Antistine)


Synthesis


Properties and uses: Antazoline hydrochloride is a white crystalline powder, sparingly soluble in water, soluble in alcohol, and slightly soluble in methylene chloride. The phosphate salt is soluble in water, bitter taste. It is used for the treatment of rhinitis and conjunctivitis.

Assay: Dissolve the sample in alcohol and titrate against 0.1 M alcoholic potassium hydroxide using phenolphthalein as indicator.

Dose: Usual dose is 50–100 mg per day.

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