Hydrogen Bonding

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Chapter: Medicinal Chemistry : Hydrogen Bonding

Hydrogen bond (H-bond) is a bond in which a hydrogen atom serves to hold two other atoms together.


Hydrogen Bonding

INTRODUCTION

Hydrogen bond (H-bond) is a bond in which a hydrogen atom serves to hold two other atoms together. The H-bond usually is formed only between hydrogen and electronegative atoms. In addition, the atoms capable of forming H-bonds have at least one unshared pair of electrons. The most common atoms capable of forming H-bonds are F, O, N, and to a lesser extent Cl and S.

The compounds that are capable of forming hydrogen bonding are only soluble in water. Proteins are held in a specific configuration by H-bonds, and denaturations of proteins involve the treating of some bonds.


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