Monobactams

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Chapter: Essential pharmacology : Betalactam Antibiotics

Aztreonam : It is a novel βlactam antibiotic in which the other ring is missing (hence monobactam). It inhibits gram-negative enteric bacilli and H. influenzae at very low concentrations and Pseudomonas at moderate concentrations.


MONOBACTAMS

 

Aztreonam

 

It is a novel βlactam antibiotic in which the other ring is missing (hence monobactam). It inhibits gram-negative enteric bacilli and H. influenzae at very low concentrations and Pseudomonas at moderate concentrations, but does not inhibit gram-positive cocci or faecal anaerobes. Thus, it is a βlactam antibiotic with a spectrum resembling aminoglycosides. It is resistant to gram-negative βlactamases. The main indications of aztreonam are hospitalacquired infections originating from urinary, biliary, gastrointestinal and female genital tracts.

 

Lack of cross sensitivity with other βlactam antibiotics except possibly ceftazidime is the most prominent feature of aztreonam: permiting its use in patients allergic to penicillins or cephalosporins. Rashes and rise in serum aminotransferases are the notable adverse effects. It is eliminated in urine with a t½ of 1.8 hr.

 

Dose: 0.5–2 g i.m. or i.v. 6–12 hourly.

 

AZENAM, TREZAM 0.5, 1.0, 2.0 g/vial inj.

 

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