Regulation of Secretion - Androgens

| Home | | Pharmacology |

Chapter: Essential pharmacology : Androgens and Drugs for Erectile Dysfunction

Testosterone is secreted by the interstitial (Leydig) cells of the testes under the influence of pulsatile secretion of LH from pituitary. FSH is mainly responsible for promotion of spermatogenesis in tubular (Sertoli) cells.


REGULATION OF SECRETION

 

Testosterone is secreted by the interstitial (Leydig) cells of the testes under the influence of pulsatile secretion of LH from pituitary. FSH is mainly responsible for promotion of spermatogenesis in tubular (Sertoli) cells. The mediator of feedback relationship with pituitary is uncertain. While relatively high concentration of testosterone inhibits LH secretion and in time causes atrophy of interstitial cells, it has only weak inhibitory action on FSH secretion. Estrogens are more potent inhibitors of Gn secretion even in males and it is believed that the small amount of estradiol produced by testes and that resulting from conversion of testosterone to estradiol plays a role in feedback inhibition. Inhibin, (a protein) produced by Sertoli cells, has strong FSH inhibitory action and may be mediating the feedback inhibition. Testosterone and estradiol act on hypothalamus to reduce GnRH as well as act directly on pituitary. The plasma level of testosterone in adult males ranges from 0.3 to 1 μg/dl and in females from 20 to 60 ng/dl.


 

Contact Us, Privacy Policy, Terms and Compliant, DMCA Policy and Compliant

TH 2019 - 2022 pharmacy180.com; Developed by Therithal info.