The Humoral Adaptive Immune System

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Chapter: Pharmaceutical Microbiology : Immunology

The humoral immune response is mediated through antibody–antigen interactions.


THE HUMORAL ADAPTIVE IMMUNE SYSTEM

The humoral immune response is mediated through antibody–antigen interactions. B-lymphocytes in their naive state, unstimulated by antigen, possess antibody molecules on their cell membrane, which serve a surveillance function to recognize any invading antigen. A B-lymphocyte that has bound antigen is capable of differentiating into a plasma cell which, under the influence of signals from helper T-cells, produces a fuller repertoire of antibody molecules (i.e. a fuller range of antibody classes), which are then secreted from the plasma cell into the extracellular environment to bring about a range of humoral effector functions.

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