Alternative methods are being developed for the detection of parasites; these include mass spectrometry (MS) and biosensors. MS can be used by identifying known surface characteristics of appropriate life cycle forms.
ALTERNATIVE METHODS
Alternative methods are
being developed for the detection of parasites; these include mass spectrometry
(MS) and biosensors. MS can be used by identifying known surface
characteristics of appropriate life cycle forms. This type of MS uses low energy
electrons to generate a fingerprint of the cells. Other mass spectrometry
methods can generate fingerprints based on parasite-derived peptides and
metabolites. These can be detected easily with a high level of sensitivity and
can be used in complex mixtures that would be present in clinical and environmental
samples. Over the past 10 years the production of kits for near patient testing
has driven the development of detection technology and this has generated
interest in the use of biosensors. These sensors detect the presence of ‘marker
molecules’ that are specific to a particular pathogen and utilize mechanical,
electro-chemical or piezoelectric methods to generate a signal that can be
detected. Such sensors can be combined onto ‘chips’ to detect a range of
pathogens.
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