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Chapter: Medicinal Chemistry : Antineoplastic Agents

Enzymes: L-Asparaginase

Antineoplastic Agents - SYNTHESIS AND DRUG PROFILE




It is an enzyme isolated from Escherichia coli and Erwinia carotovora. The enzyme has a molecular mass of 130,000. It consists of four equivalent subunits. It breaks down asparagin to aspartic acid and ammonia. It is active against tumour cells having lost the capacity to synthesize asparagines.

Properties and uses: It is used to treat childhood acute lymphocytic leukaemia in combination with vincristine and prednisone.

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