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Chapter: Medicinal Chemistry : Antineoplastic Agents

Antineoplastic Agents: Hydroxy Urea, Gallium Nitrate, Cisplastin, Carboplatin

Antineoplastic Agents - SYNTHESIS AND DRUG PROFILE



Hydroxy Urea


Uses: It is active against melanoma and chronic myelocytic leukaemia.

Gallium Nitrate

Ga (NO3)3 . 9H2O

Uses: It is used to treat cancer-related hypocalcaemia.




Properties and uses: Cisplatin is a yellow powder or yellow or orange-yellow crystals, slightly soluble in water, sparingly soluble in dimethylformamide, and practically insoluble in alcohol, used in testicular tumour.

Assay: It is assayed by adopting liquid chromatography technique.

Dosage forms: Cisplatin injection B.P.




Properties and uses: Carboplatin is a colourless crystalline powder, sparingly soluble in water, very slightly soluble in acetone and alcohol. Food and Drug Administration (FDA) approved it for treatment of advanced ovarian cancer. It is cross-resistant with cisplatin in this tumour. Activity also has been reported in lung cancer, head and neck cancer, and testicular cancer. The usual dose-limiting toxicity is bone marrow suppression, especially, thrombocytopenia.

Assay: It is assayed by gravimetric method.

Dosage forms: Carboplatin injection B.P.

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