A pro-drug is a chemically modified inert precursor of the drug that on biotransformation liberates the pharmacologically active parent compound.
Pro-Drugs INTRODUCTION A pro-drug is a chemically modified inert precursor of the drug that on biotransformation liberates the pharmacologically active parent compound. A pro-drug is also called as pro-agent, bio-reversible derivative, or latentiated drug. The design of pro-drug approach is also called as drug latentiation. The ideal properties of pro-drugs are as follows: Drug and the carrier linkage must be cleared in vivo. It should not have intrinsic pharmacologic activity. It should rapidly transform, chemically or enzymatically, into the active form where desired The metabolic fragments, apart from the active drug, should be nontoxic.Ideal Properties
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