Highly Purified Insulin Preparations

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Chapter: Essential pharmacology : Insulin, Oral Hypoglycaemic Drugs and Glucagon

In the 1970s improved purification techniques were applied to produce highly purified and practically nonantigenic insulins. Pork insulin, being more homologous to human insulin, is less immunogenic and is used.


HIGHLY PURIFIED INSULIN PREPARATIONS

 

In the 1970s improved purification techniques were applied to produce highly purified and practically nonantigenic insulins. Pork insulin, being more homologous to human insulin, is less immunogenic and is used. Gel filtration reduces proinsulin content to 50–200 ppm, but pancreatic peptides and insulin derivates remain; the preparation is called ‘single peak insulin’. It still has significant immunogenicity. Further purification by ion-exchange chromatography removes most contaminants and reduces proinsulin to <10 ppm. These preparations are termed ‘Highly purified’ or ‘Monocomponent (MC) insulins’. Immunogenicity of pork MC insulins is similar to that of human insulins. Moreover, MC insulins are more stable, cause less insulin resistance or injection site lipodystrophy.

 

1. Highly purified (monocomponent) pork regular insulin: ACTRAPID MC, RAPIDICA 40 U/ml inj.

 

2. Highly purified (MC) pork lente insulin: LENTARD, MONOTARD MC, LENTINSULINHPI, ZINULIN 40 U/ml

 

3. Highly purified (MC) pork isophane (NPH) insulin: INSULATARD 40 U/ml inj.

 

4. Mixture of highly purified pork regular insulin (30%) and isophane insulin (70%): RAPIMIX, MIXTARD 40 U/ml inj.

 

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