Highly Purified Insulin Preparations
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In the 1970s improved purification techniques were applied to produce highly purified and practically nonantigenic insulins. Pork insulin, being more homologous to human insulin, is less immunogenic and is used.
HIGHLY PURIFIED INSULIN PREPARATIONS
In the 1970s improved
purification techniques were applied to produce highly purified and practically
nonantigenic insulins. Pork insulin, being more homologous to human insulin, is
less immunogenic and is used. Gel filtration reduces proinsulin content to
50–200 ppm, but pancreatic peptides and insulin derivates remain; the
preparation is called ‘single peak
insulin’. It still has significant immunogenicity. Further purification by
ion-exchange chromatography removes most contaminants and reduces proinsulin to
<10 ppm. These preparations are termed ‘Highly
purified’ or ‘Monocomponent (MC) insulins’.
Immunogenicity of pork MC insulins is similar to that of human insulins.
Moreover, MC insulins are more stable, cause less insulin resistance or
injection site lipodystrophy.
1. Highly
purified (monocomponent) pork regular insulin: ACTRAPID MC, RAPIDICA
40 U/ml inj.
2. Highly
purified (MC) pork lente insulin: LENTARD, MONOTARD MC, LENTINSULINHPI,
ZINULIN 40 U/ml
3. Highly purified (MC) pork isophane (NPH) insulin:
INSULATARD
40 U/ml inj.
4. Mixture
of highly purified pork regular insulin (30%) and isophane insulin (70%): RAPIMIX, MIXTARD 40 U/ml inj.
