Mixed Antigens

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Chapter: Essential pharmacology : Vaccines And Sera

Double Antigen (DTDA) : It consists of alum precipitated toxoids of tetanus and diphtheria, available in 0.5 ml ampule and 5 ml vial (DUAL ANTIGEN). It is used in children above 5 years and in younger children in place of triple antigen when pertussis vaccine is contraindicated.


MIXED ANTIGENS

 

Double Antigen (DTDA)

 

It consists of alum precipitated toxoids of tetanus and diphtheria, available in 0.5 ml ampule and 5 ml vial (DUAL ANTIGEN). It is used in children above 5 years and in younger children in place of triple antigen when pertussis vaccine is contraindicated.

 

Dose: 0.5 ml i.m.

 

Triple Antigen (DPT)

 

It is a mixture of toxoids of tetanus and diphtheria with pertussis vaccine (TRIPVAC: Diphtheria toxoid 25 Lf, tetanus toxoid 5 Lf, B. pertussis 20,000 million in 0.5 ml amp; also 10 ml multidose vial).

 


 

It is the preparation of choice for primary active immunization against the 3 diseases in children below 5 years age. Dose–0.5 ml i.m. in the anterolateral aspect of mid thigh or right deltoid, 2–3 injections 4–8 weeks apart, between 3–9 months age and one at 18 months. Reactions, precautions and contraindications mentioned under the individual vaccines apply to triple antigen as well.

 

A routine immunization schedule for infants and children is given in the box above.

 

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