Anthranilic Acid Derivative (Fenamate)
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An analgesic, antipyretic and weaker anti-inflammatory drug, which inhibits COX as well as antagonises certain actions of PGs. Mephenamic acid exerts peripheral as well as central analgesic action.
ANTHRANILIC ACID DERIVATIVE
(FENAMATE)
Mephenamic Acid
An analgesic,
antipyretic and weaker anti-inflammatory
drug, which inhibits COX as well as antagonises certain actions of PGs.
Mephenamic acid exerts peripheral as well as central analgesic action.
Adverse Effects
Diarrhoea is the most important
doserelated side effect. Epigastric distress is complained, but gut bleeding is
not significant. Skin rashes, dizzines and other CNS manifestations have
occurred. Haemolytic anaemia is a rare but serious complication.
Pharmacokinetics
Oral absorption is
slow but almost complete. It is
highly bound to plasma proteins—displacement interactions can occur; partly
metabolized and excreted in urine as well as bile. Plasma t½ is 2–4 hours.
Uses
Mephenamic acid is
indicated primarily as analgesic in muscle,
joint and soft tissue pain where strong anti-inflammatory action is not needed.
It is quite effective in dysmenorrhoea. It may be useful in some cases of
rheumatoid and osteoarthritis but has no distinct advantage.
Dose: 250–500 mg TDS; MEDOL 250, 500
mg cap;
MEFTAL 250, 500 mg
tab, 100 mg/5 ml susp.
PONSTAN 125, 250, 500
mg tab, 50 mg/ml syrp.
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