Classification of Antifungal Agents

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Chapter: Medicinal Chemistry : Antifungal Agents

On the basis of some differences, fungi may be classified as follows: a. Phyco myelitis (algae-like) b. Asco myelitis (sac-like) c. Basidio myelitis (mushrooms) d. Duetero myelitis


On the basis of some differences, fungi may be classified as follows:

a.            Phyco myelitis (algae-like)

b.           Asco myelitis (sac-like)

c.            Basidio myelitis (mushrooms)

d.           Duetero myelitis

The potentially effective antifungal compounds are listed in Table 5.1.


Classification Based on the Chemical Structure, Action, and Source

The antifungal agents can be divided into the following classes, based on their chemical structure, mechanism of action, and source:

I. Antibiotics: Amphotericin B, Nystatin, Griseofulvin

II. Azoles (imidazole, triazole derivates)

Table 5.1 Potentially effective antifungal compounds.

Triazoles—Fluconazole, Itraconzole, Terconazole

Imidazoles—Clotrimazole, Ketoconazole, Miconazole, Bifonazole, Butoconazole, and Zinoconazole

III. Fluorinated pyrimidines: Flucytosine

IV. Chitin synthetase inhibitors: Nikomycin Z

V. Peptides/proteins: Cispentacin

VI. Miscellaneous: Ciclopirox, Tolnaftate, Naftifine, and Terbinafine


Classification Based on the Route of Administration

I. Drugs for subcutaneous and systemic mycoses: Amphotericin B, Fluconazole, Flucytosine, Itraconazole, Ketoconazole.

II. Drugs for superficial mycoses: Clotrimazole, Econazole, Griseofluvin, Miconazole, Nystatin.

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