Drugs For Vertigo
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The therapy of vertigo occurring in Méniére’s disease and other conditions is imperfect. A variety of approaches have been tried and have met with partial success.
DRUGS FOR
VERTIGO
The
therapy of vertigo occurring in Méniére’s disease and other conditions is
imperfect. A variety of approaches have been tried and have met with partial
success.
1. Labyrinthine
Suppressants
They suppress endorgan receptors or inhibit
central cholinergic pathway (in vestibular nuclei).
a. Antihistaminics (with anticholinergic
action)— cinnarizine, cyclizine,
dimenhydrinate, diphenhydramine, promethazine.
b. Anticholinergics—atropine, hyoscine.
c. Antiemetic phenothiazines—prochlorperazine,
thiethylperazine.
2. Vasodilators
They improve blood flow to labyrinth and brainstem—betahistine,
codergocrine, nicotinic acid, naftidrofuryl.
3. Diuretics
They decrease labyrinthine fluid pressure —acetazolamide, thiazides, furosemide.
4. Anxiolytics, Antidepressants
These drugs appear to modify the
sensation of vertigo—diazepam, amitriptyline.
5. Corticosteroids
They suppress intra-labyrinthine edema due to viral infection or other causes.
Parenteral
prochlorperazine is the most effective drug for controlling violent vertigo and
vomiting.
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