Midazothiazoles

Anthelmintics - Synthesis and Drug Profile

Midazothiazoles

Levamisole (Bizole, Vermisol)

Synthesis:

Mode of action: It stimulates the ganglion in the worms, causes tonic paralysis, which results in the expulsion of live worms. These also interfere with the carbohydrate metabolism by inhibiting fumarate reductase.

Dose: The administered dose is 15 mg as a single dose, repeated after 1 month to prevent recurrence.