Amides : Niclosamide (Niclocide) - Synthesis and Drug Profile
Synthesis
Mode of action: Niclosamide is also a potent mollusicide, which
is effective against Biomphaloria
glabrata, the principle action of the drug may be to inhibit anaerobic
phosphorylation of adenosine diphosphate (ADP) by the mitochondria of the
parasite, an energy producing process.
Properties and uses: Niclosamide exists as yellowish fine crystals,
practically insoluble in water, sparingly soluble in acetone, and slightly
soluble in ethanol. It is used as an anthelmintic.
Assay: Dissolve the sample in a mixture of equal volumes of acetone and
methanol and titrate with 0.1 M tetrabutylammonium hydroxide. Determine the end
point potentiometrically.
Dose: The dose orally to be taken after meals is 2 g chewable tablets.
Dosage forms: Niclosamide tablets B.P.
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