Organophosphorus compounds
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Organophosphorus compounds: Metrifonate (Bilacil) - Synthesis and Drug Profile
Anthelmintics - Synthesis and Drug Profile
Organophosphorus compounds
Metrifonate (Bilacil)
Synthesis
Mode of action: Metrifonate is metabolized and rearranged in
vivo to dichlorvos, which inhibits acetyl cholinesterase.
Properties and uses: Metrifonate is a white crystalline powder,
soluble in water, in acetone, and in alcohol, and very soluble in methylene
chloride, used as an anthelmintic.
Assay: Dissolve the sample in alcohol, add ethanolamine, and allow to
stand for 1 h at 20°C–22°C. Add chilled nitric acid maintaining the temperature
of the mixture at 20°C–22°C and titrate with 0.1 M silver nitrate. Determine
the end point potentiometrically.
Doses: The recommended dose is 7.5 to 10 mg/kg given orally three times
at intervals of 2 weeks.
