SAR of Hydantoins
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5-phenyl or other aromatic substitution is essential for activity.
SAR of Hydantoins 5-phenyl or other aromatic substitution is essential for activity. Alkyl substituent at position 5 may contribute to sedation, a property absent in phenytoin. Among other hypnotics 1,3-disubstituted hydantoins, exhibit activity against chemically induced convulsion, while it remains ineffective against electric shock induced convulsion.
