5-phenyl or other aromatic substitution is essential for activity.
SAR of Hydantoins 5-phenyl or other aromatic substitution is essential for activity. Alkyl substituent at position 5 may contribute to sedation, a property absent in phenytoin. Among other hypnotics 1,3-disubstituted hydantoins, exhibit activity against chemically induced convulsion, while it remains ineffective against electric shock induced convulsion.
TH 2019 - 2024 pharmacy180.com; Developed by Therithal info.