Various substituents that are tested on the phenyl acetyl urea and their SAR is discussed as given:
SAR of Phenacemide Various substituents that are tested on the phenyl acetyl urea and their SAR is discussed as given: Among aliphatic acetyl ureas the highest anticonvulsant activity is found in those derived from the branched chain acids of about 7-carbon atoms. With a further increase in molecular weight the anticonvulsant activity gradually terminates and hypnotic effect predominates. Phenacemide is a most active agent among the aromatic acetyl urea. Any substitution in nitrogen of phenacemide does not increase further the anticonvulsant activity. The activity decreases with aromatic substituents of phenacemide with a gradual increase in hypnotic activity.
TH 2019 - 2023 pharmacy180.com; Developed by Therithal info.