Benzodiazepines
| Home | | Medicinal Chemistry |Chapter: Medicinal Chemistry : Anticonvulsants
Anticonvulsants - Benzodiazepines : Clobazam (Frisium, Lobazam, Cloba) - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile
SYNTHESIS AND DRUG PROFILE
Benzodiazepines
Mode of action: Benzodiazepines acts by enhancing pre and postsynaptic inhibition through benzo-diazepine receptor, which is an integral part of GABA-A receptor Cl– channel. It opens the Cl– channel through GABA facilitatory action. These drugs also induce hyper-polarization and decrease firing rate of neurons.
Metabolism of Benzodiazepines is discussed in section III, Chapter Sedatives and Hypnotics.
a. Clobazam (Frisium, Lobazam, Cloba)
Synthesis
Uses: It is used in the treatment of partial and generalized epilepsy.
Dose: The usual dose for adult is 20 to 30 mg daily.
