Tetracyclines
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These antibiotics have slowly acting and weak erythrocytic schizontocidal action against all plasmodial species. In addition, pre-erythrocytic stage of P. falciparum is inhibited.
TETRACYCLINES
These antibiotics have
slowly acting and weak erythrocytic schizontocidal action against all
plasmodial species. In addition, pre-erythrocytic stage of P. falciparum is inhibited. They are never used alone to treat
malaria, but only in combination with quinine or S/P for the treatment of
chloroquine resistant falciparum malaria. Tetracycline 250 mg QID or
doxycycline 100 mg OD are equally efficacious. Doxycycline 200 mg/ day has also
been combined with artesunate to treat mefloquine/chloroquine/S/Presistant
falciparum malaria in Thailand.
Doxycycline 100 mg/day
is used as a 2nd line prophylactic for travellers to chloroquine-resistant P. falciparum areas.
