Prostaglandins

| Home | | Medicinal Chemistry |

Chapter: Medicinal Chemistry : Prostaglandins

Prostaglandins (PGs) occur virtually in all mammalian tissues and possess numerous and diverse pharmacological actions.


Prostaglandins

INTRODUCTION

Prostaglandins (PGs) occur virtually in all mammalian tissues and possess numerous and diverse pharmacological actions. They are comprised of a large number of unsaturated hydroxy, lipids like acids containing 20 carbon atoms. Since they were extracted from prostate gland and seminal vesicles of several animal species, including that of human semen, the term prostaglandin was used for them. It is isolated and purified as hydroxy fatty acid fraction from lipid extracts of seminal vesicles and from it the two biologically active substances, that is, PG E and F, were isolated. Some active compounds were derived from oxygenation of arachidonic acid, a precursor released from membrane phospholipids. The anti-inflammatory and analgesic effects of aspirin and the related nonsteroidal anti-inflammatory drugs (NSAIDs) are due to their inhibitory effects on PG formation.

They are also reported to be present in significant quantities in the reproductive tissues, developing foetus and deciduals, umbilical cord, amniotic fluid, endometrium, menstrual fluid, epidermis, thymus, thyroid, and nerves. Further, in most of the organs, except for genital tissue, the PG is present as prostaglandin E (PGE) and prostaglandin F2 (PGF2). Therapeutic potential of PGs are in the treatment of blood pressure, bronchial functions, atherosclerosis, heart attack, inhibition of blood clot formation, childbirth, abortions, stomach ulcers, and other related syndromes.

Contact Us, Privacy Policy, Terms and Compliant, DMCA Policy and Compliant

TH 2019 - 2022 pharmacy180.com; Developed by Therithal info.