Oral Hypogylcaemic Drugs : Aldose reducatse inhibitors - i. Sorbinil ii. Tolrestat
In diabetic
complications, high concentrations of glucose is converted into sorbitol by
aldose reductase by the polyol pathway
(Fig. 1.4). Sorbitol is converted into fructose and these products accumulate
in the nerves, kidneys, and retina, etc. Galactone is converted to galacitol,
which is not metabolized and causes osmotic swelling. Aldose reductase
inhibitors interfere in the polyol pathway of sorbitol and fructose and thereby
cause hypoglycaemic effects.
Uses: It is used in the treatment of diabetic neuropathy.
Uses: It is useful in the prophylaxis of diabetic neuropathy and
cataracts.
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