The discovery or design of new drugs requires a design process along with the synthetic techniques, methods of administration, development of tests, and further procedures to establish pharmacodynamics and their toxicological assessment.
Concepts of Drug Design INTRODUCTION The discovery or design of new drugs requires a design process along with the synthetic techniques, methods of administration, development of tests, and further procedures to establish pharmacodynamics and their toxicological assessment. The diversity in synthetic chemistry is ever increasing as a result of the increase in the number of chemical compounds, which requires a sequence of screening modules with appropriate time consumption and affidavits little success. These consequences made it necessary to find out the possibilities for the development of new, logical, and scientific approaches in the discovery of new molecules or drugs and came to be known as drug designing. Drug design is an integrated advancing discipline, in which a biologically active molecule is produced by chemical synthesis followed by an evaluation of its activity and toxicological studies with the limitation of trial-and-error screening. In the broader sense, it implies the random evaluation of congeners produced from the lead molecule either by implementing tailor-made techniques or by applying the basic concepts of physicochemical properties to produce an able molelcule.
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