Other Hyperglycaemics
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Diazoxide : It inhibits insulin release from β cells and causes hyperglycaemia lasting 4–8 hours. Its action on ATP sensitive K+ channels is opposite to that of sulfonylureas.
OTHER HYPERGLYCAEMICS
Diazoxide
It
inhibits insulin release from β cells and causes hyperglycaemia lasting 4–8 hours. Its action on
ATP sensitive K+ channels is opposite to that of sulfonylureas. Other actions
which may contribute to hyperglycaemia are decreased peripheral utilization of
glucose and release of catecholamines. It has been used to prevent hypoglycaemia
in insulinomas.
Thiazide diuretics and phenytoin
These
are also mild hyperglycaemics.
Somatostatin
It
causes hyperglycaemia primarily by inhibiting insulin
release.
Streptozocin
It
is obtained from Streptomyces
achromogenes. Causes selective damage to insulin secreting β cells. It has been
used to produce experimental diabetes in animals and to treat insulin secreting
tumours of pancreas.
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