The preparation of toothpastes may be carried out by using two methods which are as follows:
PREPARATION
OF TOOTHPASTE
The preparation of toothpastes may
be carried out by using two methods which are as follows:
·
Dry
gum method.
·
Wet
gum method.
1.
Dry Gum Method:
In this method, all the solid
components of the formulation like abrasive agent, binding agent etc., except
the surfactants are mixed together in a dry mixer. The mixer may be an
agitation mixer which consists of slow rotating blades.
The liquid components such as the
humectants and water are gradually added to the dry mix.
The mixing process is carried out
till a smooth paste is formed.
The remaining ingredients like the
surfactants and the flavouring agents are added to the homogenous paste under
vacuum.
2.
Wet Gum Method:
In this method, all the liquid
components are mixed together to form a liquid phase. The binding agent is then
mixed with the liquid phase with uniform stirring in order form mucilage.
The solid ingredients excluding the
surfactants are then gradually added to the mucilage with uniform mixing in an
agitation mixer, in order to form a homogenous paste.
The remaining ingredients i.e., the
surfactants, the flavoring agents, coloring agents are added under vacuum t the
homogenous paste.
Based on the principle involved in
the above methods, some acceptable techniques have been proposed for the
manufacture of toothpaste which is as follow:
1.
Cold compression technique: The preparation of toothpaste using
this technique can be carried out as
follows.
Initially, the humectants such as
sorbitol (70% w/v) or glycerine are taken in the bowl of the mixer.
The binding agent is then sprinkled
over the humectant under agitation for uniform dispersion.
The liquid components such as water,
sweetener and the preservatives are mixed to form a separate liquid phase and
any therapeutic additives if necessary are also added to the liquid phase.
This liquid phase is then added to
the humectant-binder mixture in the bowl and mixing is carried out for 5
minutes in order to remove the air from the thick gelatinous liquid phase.
The vacuum is stopped and the
abrasive agents are added with constant mixing until they are completely
dissolved.
The vacuum is reapplied and mixing
is continued for at least 30 minutes.
The surfactants and the flavouring
agents are dispersed separately in 5% humectant. This mixture is added to the
vacuum at the end and 5 minutes of additional mixing is carried out.
Finally, it leads to the formation
of an air free smooth paste.
2.
Multiple Liquid Phase technique: This method is suitable for formulations
that make use of carboxy methyl
cellulose (CMC) and magnesium aluminium silicate hinder combination. The
preparation can be carried out as follows:
Initially, hot water is taken in a
mixer bowl and magnesium aluminium silicate is added to it.
The humectants, the flavouring agent,
the binding agent and the preservatives are mixed separately to form a separate
liquid phase.
This solution is then added to the
mixer and the final volume is made using the humectants.
Vacuum is introduced into bowl in
order to remove the air from the liquid mixture. The vacuum is removed and the
abrasive agents are added and the vacuum is again introduced in the mixed for
30 minutes.
Finally, the surfactants are added
with constant inking for 5 minutes. The method is also suitable for the
preparation of clear-gel dentifrices.
3.
Hot Liquid Phase Technique: The method preparation using this
technique is as follows:
In this method, the abrasive agent,
binding agent and preservatives are mixed separately in a dry mixer.
The humectant, sweeteners and water
are mixed separately and this liquid phase is heated.
The hot solution is then slowly added
to dry powder with constant mixing.
The resultant mass is then mixed
under vacuum for 30 minutes.
Finally, the solutions of the
flavouring agent and the surfactant are added and vacuum, mixing is carried out
for 5 more minutes.
A clear and homogeneous paste is
formed by this method.
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