SAR of Aminoglycoside Antibiotics
| Home | | Medicinal Chemistry |Chapter: Medicinal Chemistry : Antibiotics
The aminoglycosides consist of two or more amino sugars joined in glycoside linkage to a highly substituted 1,3-diaminocyclo hexane (aminocyclitol), which is a centrally placed ring.
SAR of Aminoglycoside Antibiotics
The aminoglycosides consist of two or more amino sugars joined in glycoside linkage to a highly substituted 1,3-diaminocyclo hexane (aminocyclitol), which is a centrally placed ring. The ring is a 2-deoxy streptamine in all aminoglycosides except streptomycin and dihydrostreptomycin, where it is streptidine.
Thus,
·In kanamycin and gentamycin families, two amino
sugars are attached to 2-deoxy streptamine.
·In streptomycin, two amino sugars are attached
to strepidine.
·In neomycin family, there are amino sugars
attached to 2-deoxy streptamine.
The
aminoglycoside antibiotics contain two important structural features. They are amino
sugar portion and centrally placed hexose ring, which is either
2-deoxystreptamine or streptidine.
Related Topics
