Third-generation cephalosporins
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i. Cefotaxime Sodium ii. Ceftizoxime sodium iii. Ceftriazone disodium
Cephalosporins - Synthesis and Drug Profile
Third-generation cephalosporins
i. Cefotaxime Sodium
Synthesis
Properties and uses: Cefotaxime sodium exists as white solid and
soluble in water, exhibits broad-spectrum activity against both gram-positive
and gram-negative bacteria. Used in genitourinary infection and lower
respiratory infection.
ii. Ceftizoxime sodium
Synthesis
Properties and uses: It is a beta lactamase resistant cephalosphorin,
used in lower respiratory infection and meningitis.
iii. Ceftriazone disodium
Synthesis
Properties and uses: It exists as white crystals, soluble in water,
exhibits broad-spectrum activity against both gram-positive and gram-negative
bacteria.
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