Tissue storage
| Home | | Pharmacology |Chapter: Essential pharmacology : Pharmacokinetics; Membrane Transport, Absorption And Distribution Of Drugs
Drugs sequestrated in various tissues are differentially distributed, tend to have large volume of distribution and long duration of action...
TISSUE STORAGE
Drugs may also
accumulate in specific organs by
active transport or get bound to specific tissue constituents (see box).
Drugs sequestrated in
various tissues are differentially distributed, tend to have large volume of
distribution and long duration of action. Some may exert local toxicity due to
high concentration, e.g. tetracyclines on bone and teeth, chloroquine on
retina, streptomycin on vestibular apparatus, emetine on heart and skeletal
muscle. Drugs may also selectively bind to specific intracellular organelle,
e.g. tetracycline to mitochondria, chloroquine to nuclei.
