Benzodiazepines

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Chapter: Medicinal Chemistry : Anticonvulsants

Anticonvulsants - Benzodiazepines : Clobazam (Frisium, Lobazam, Cloba) - Synthesis and Drug Profile - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile


SYNTHESIS AND DRUG PROFILE


Benzodiazepines

Mode of action: Benzodiazepines acts by enhancing pre and postsynaptic inhibition through benzo-diazepine receptor, which is an integral part of GABA-A receptor Cl channel. It opens the Cl channel through GABA facilitatory action. These drugs also induce hyper-polarization and decrease firing rate of neurons.

Metabolism of Benzodiazepines is discussed in section III, Chapter Sedatives and Hypnotics.


a. Clobazam (Frisium, Lobazam, Cloba)


Synthesis


Uses: It is used in the treatment of partial and generalized epilepsy.

Dose: The usual dose for adult is 20 to 30 mg daily.


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