Mecillinam (Amdinocillin)

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Chapter: Medicinal Chemistry : Antibiotics

Mecillinam is particularly active against enterobacteria including some ampicillin resistant strains and to treat urinary tract infections.


Penicillin - Synthesis and Drug Profile

Miscellaneous penicillins

 

i. Mecillinam (Amdinocillin)


Synthesis


Properties and uses: Mecillinam is particularly active against enterobacteria including some ampicillin resistant strains and to treat urinary tract infections. It is structurally different from other penicillins, in that, it is not an acyl derivative, but rather alkylidene amino-(amidino) derivative of 6-APA, due to this difference, it has signi´Čücant gram-negative antibacterial activity as compared to gram-positive antibacterial activity.

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