Drugs Acting on Uterus

Drugs acting on uterus can primarily affect the endometrium or the myometrium. The most important drugs affecting endometrium are estrogens, progestins and their antagonists. Myometrium receives both sympathetic and parasympathetic innervation: autonomic drugs can affect its motility. However, directly acting drugs are more important and have more selective action. The responsiveness of myometrium to drugs is markedly affected by the hormonal and gestational status.