Prostaglandins - Uterine Stimulants
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PGE2, PGF2α and 15methyl PGF2α are potent uterine stimulants, especially in the later part of pregnancy and cause ripening of cervix.
PROSTAGLANDINS
PGE2, PGF2α and 15methyl PGF2α are potent uterine
stimulants, especially in the later part of pregnancy and cause ripening of
cervix. Their actions and use in obstetrics is described in Ch. No. 13. Since
misoprostol (a PG analogue used for peptic ulcer) produces less side effects,
it is being used for obstetric indications also.
Ethacridine
Available as 50 mg/50
ml solution (EMCREDIL, VECREDIL) for extraamniotic
infusion: 150 ml (containing 150 mg) is injected slowly for medical termination
of pregnancy in the 2nd trimester. This is an alternative method used
occasionally.
