Other Drugs for Hypercalcaemia
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Gallium nitrate: It is a potent inhibitor of bone resorption; acts by depressing ATPdependent proton pump at the ruffled membrane of osteoclasts. Indicated in resistant cases of hypercalcaemia.
OTHER DRUGS
FOR HYPERCALCAEMIA
Gallium nitrate: It is a potent inhibitor of bone resorption; acts by depressing ATPdependent
proton pump at the ruffled membrane of osteoclasts. Indicated in resistant
cases of hypercalcaemia, it is given by continuous i.v. infusion daily for 5
days. It is nephrotoxic and only a reserve drug.
Mithramycin (Plicamycin) A cytotoxic drug which inhibits bone resorption in 10 times lower doses
than for cancer. It is used only in nonresponsive cases of hypercalcaemia and
Paget’s disease. Toxicity is high.
Glucocorticoids: High doses of prednisolone (and others) enhance calcium excretion, decrease
calcium absorption and have adjuvant role in hypercalcaemia due to lymphoma,
myeloma, leukaemia, carcinoma breast, etc.
