Luminal amoebicdes
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Antiamoebic Agents - Luminal amoebicdes: Diloxanide Furoate (Furamide)
Antiamoebic Agents - Synthesis
and Drug Profile
Luminal amoebicdes
i. Diloxanide Furoate (Furamide)
Synthesis
Metabolism: The diloxanide furoate is administered orally and is hydrolyzed
in the gut to give diloxanide.
Properties and uses: Diloxanide furoate is a white crystalline
powder, very slightly soluble in water, slightly soluble in ethanol and ether.
It is dichloro acetamide derivative that is nontoxic, mainly used in the
treatment of chronic amoebiasis. It is less effective in the treatment of acute
intestinal amoebiasis.
Assay: Dissolve the sample in anhydrous pyridine and titrate against
0.1 M tetrabutylammonium hydroxide. Determine the end point potentiometrically.
Dose: The recommended oral dose is 500 mg three times daily for 10
days (Diloxanide furoate 250 mg +
Tinidazole 300 mg) two tablets daily. Diloxanide furoate 250 mg + Metronidazole
250 mg two tablets thrice daily for 10 days.
Dosage forms: Diloxanide tablets B.P.
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