Acridine Derivatives: Quinacrine - Synthesis and Drug Profile
Acridine Derivatives
Synthesis
Mode of action: Quinacrine acts at many sites within the cell,
including intercalation of DNA strands, succinic dehydrogenase, mitochondrial
electron transport, and cholinesterase. It may be tumerogenic and mutagenic and
has been used as a sclerosing agent. Because it is an acridine dye, quinacrine
can cause yellow discolouration of the skin and urine.
Properties and uses: It acts as a schizontocidal and now it is not
used as an antimalarial agent. It is used in the treatment of leishmaniasis and
some tape worm infestations.
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