Sulphones and sulphonamides
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They only act against the erythrocytic stages of malaria parasite. The sulphadoxine interferes with the parasites ability to synthesize folic acid.
Antimalarials - Synthesis and Drug Profile
Sulphones and sulphonamides
Mode of action: They only act against the erythrocytic stages of
malaria parasite. The sulphadoxine interferes with the parasites ability to
synthesize folic acid. Sulphonamides block the incorporation of pamino benzoicacid (PABA) to form
dihydropteroic acid. PABA is the central part of the folate structure.
Sulphonamides exhibit significant toxicity because humans do not synthesize the
vitamin folic acid. There are severe to fatal occurrences of erythema multiform,
Stevens-Johnson syndrome, toxic epidermal necrolysis, and serum sickness
syndromes attributed to the sulphadoxine.
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