Mechanisms of Resistance
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Resistance to antimicrobial agents typically occurs by one or more of the following mechanisms:
MECHANISMS OF RESISTANCE
Resistance to antimicrobial agents typically occurs by one or more of
the following mechanisms:
• Inactivation of the drug
• Alteration of the target
• Reduced cellular uptake
• Increased efflux
In this chapter, resistance will be examined by agent, but attention
will be drawn to mechanisms which can permit resistance to multiple, chemically
different agents.
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