Mecillinam (Amdinocillin)
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Mecillinam is particularly active against enterobacteria including some ampicillin resistant strains and to treat urinary tract infections.
Penicillin - Synthesis and Drug Profile
Miscellaneous penicillins
i. Mecillinam (Amdinocillin)
Synthesis
Properties and uses: Mecillinam is particularly active against
enterobacteria including some ampicillin resistant strains and to treat urinary
tract infections. It is structurally different from other penicillins, in that,
it is not an acyl derivative, but rather alkylidene amino-(amidino) derivative
of 6-APA, due to this difference, it has significant gram-negative antibacterial
activity as compared to gram-positive antibacterial activity.
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