Spinal Neuronal Pathways

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Chapter: Anatomy and Physiology for Health Professionals: Central Nervous System

1. Describe first-order, second-order, and third-order sensory neurons. 2. Differentiate the functions of the ascending and descending spinal pathways.

Spinal Neuronal Pathways

The primary spinal tracts or fasciculi make up multi-neuron pathways and connect the brain to the rest of the body. They contain spinal cord neurons, parts of peripheral neurons, and brain neurons. Spinal neu-ronal pathways are signified by decussation, relay, somatotopy, and symmetry. Most pathways cross from one side of the CNS to the other, which is described as decussation. Most also consist of a chain of several neurons contributing to successive pathway tracts in the relay of information. Most pathways have a precise spatial relationship among tract fibers (somatotopy), which resemble the body’s ordered mapping. Ascend-ing sensory tracts, for example, fibers that transmit inputs from sensory receptors in superior regions of the body, lie lateral to others that convey sensory infor-mation from inferior body regions. There is ­symmetry to all pathways and tracts. One member of each pair is present on either side of the brain or spinal cord.

Ascending Pathways to the Brain

Ascending pathways conduct sensory impulses toward the brain and consist of three types of neurons:

First-order neurons: These have cell bodies in a ganglion (either dorsal root or cranial root) and conduct impulses from the skin’s cutaneous recep-tors and from proprioceptors to the brain stem or spinal cord. A first-order neuron synapses with a second-order neuron.

Second-order neurons: These have cell bodies in the spinal cord’s dorsal horn or in the medullary nuclei that transmit impulses to the thalamus or cerebellum.

Third-order neurons: These have cell bodies in the thalamus and send impulses to the cerebrum. There are no third-order neurons in the cerebellum.

There are three primary types of ascending pathways on each side of the spinal cord: the dor-sal column-medial lemniscal pathways, spinothalamic pathways, and spinocerebellar pathways. The dorsal column-medial lemniscal pathways mediate precise transmission of inputs of certain sensory receptors such as for discriminative touch and vibrations. The spinothalamic pathways receive signals from many sensory receptor types, making multiple synapses in the brain stem. The spinothalamic pathways transmit temperature, touch, pain, and pressure impulses. The spinocerebellar pathways transmit information about tendon or muscle stretching to the ­cerebellum so it can coordinate the activities of the skeletal muscles.

Descending Pathways and Tracts

The descending pathways transmit impulses from the brain to the spinal cord, via direct and indirect pathways.

Upper motor neurons: These are pyramidal cells of the motor cortex as well as neurons of the subcortical motor nuclei.

Lower motor neurons: These are from the ­ventral horn and directly innervate skeletal muscles. Direct (pyramidal) pathways originate ­primarily with the pyramidal neurons in the precentral gyri and send impulses through the brain stem via large pyramidal (corticospinal) tracts.

The indirect pathways include all other motor pathways except the pyramidal pathways and brain stem motor nuclei. Formerly, indirect pathways were referred to as the extrapyramidal system; however, they are now referred to as indirect (multineuronal) pathways or may be individually named. Indirect pathways are most involved in maintaining balance and posture (via the axial muscles), coarse limb move-ments, and the following of objects in the visual field with the head, neck, and eyes. The vestibulospinal tract and reticulospinal tract use varying postural muscle tone to maintain balance. Flexor muscles are controlled by the rubospinal tracts, whereas the superior colliculi and tectospinal tracts control head movements in relation to visual stimuli. TABLE 12-3 describes the ascending and descending nerve tracts of the spinal cord. FIGURES 12-16 and 12- 17 show how these nerve tracts function between the brain, spinal cord, and sensory and motor fibers.

1. Describe first-order, second-order, and third-order sensory neurons.

2. Differentiate the functions of the ascending and descending spinal pathways.

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