the half-life of a first-order process is a constant and independent of initial drug concentration.

**First-Order Half-Life**

Substituting the value of C = C_{o}/2 at t_{½}
in equation 8.14 and solving it yields:

t_{1/2} = 0.693 / K (8.16)

Equation 8.16 shows that, in contrast to zero-order
process, the half-life of a first-order process is a constant and independent
of initial drug concentration i.e. irrespective of what the initial drug
concentration is, the time required for the concentration to decrease by
one-half remains the same (see Fig. 8.4.). The t_{½} of a first-order
process is an important pharmacokinetic parameter.

Most pharmacokinetic processes *viz*. absorption, distribution and elimination follow first-order
kinetics.

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