Biopharmaceutics and Pharmacokinetics

Pharmaceutics: Biopharmaceutics and Pharmacokinetics - Covers all topics with images and clear explanation. Study Biopharmaceutics and Pharmacokinetics Online course, study material, important questions and answers, Notes, textbook.

Biopharmaceutics and Pharmacokinetics

Chapter 1: Introduction

=> Biopharmaceutics and Pharmacokinetics

Chapter 2: Absorption of Drugs

=> Absorption of Drugs
=> Gastrointestinal Absorption of Drugs
=> Mechanisms of Drug Absorption
=> Factors Influencing Drug Absorption and Bioavailability
=> Pharmaceutical Factors
=> Physicochemical Factors Affecting Drug Absorption
=> Dosage Form (Pharmaco-Technical) Factors
=> Gastrointestinal tract
=> Patient Related Factors Affecting Drug Absorption
=> Methods for Studying Drug Uptake
=> Absorption of Drugs From Non-PER OS Extravascular Routes

Chapter 3: Distribution of Drugs

=> Distribution of Drugs
=> Tissue Permeability of Drugs
=> Organ/Tissue Size and Perfusion Rate
=> Binding of Drugs to Tissue Components
=> Miscellaneous Factors Affecting Drug Distribution
=> Volume of Distribution

Chapter 4: Protein Binding of Drugs

=> Mechanisms of Protein-Drug Binding
=> Binding of Drugs to Blood Components
=> Tissue Binding of Drugs (Tissue Localization of Drugs)
=> Determination of Protein-Drug Binding
=> Factors Affecting Protein-Drug Binding
=> Drug Related Factors
=> Protein/Tissue Related Factors
=> Drug Interactions
=> Patient Related Factors
=> Significance of Protein/Tissue Binding of Drugs
=> Kinetics of Protein-Drug Binding

Chapter 5: Biotransformation of Drugs

=> Biotransformation of Drugs
=> Chemical Pathways of Drug Biotransformation
=> Oxidative Reactions
=> Reductive Reactions
=> Hydrolytic Reactions
=> Phase II Reactions
=> Conjugation With Glucuronic Acid
=> Conjugation With Sulphate Moieties
=> Conjugation With Alpha Amino Acids
=> Conjugation With Glutathione and Mercapturic Acid Formation
=> Acetylation
=> Methylation
=> Miscellaneous Conjugation Reactions
=> Methods for the Study of Drug Biotransformation
=> Factors Affecting Biotransformation of Drugs
=> Physicochemical Properties of the Drug
=> Chemical factors of Drug
=> Biological Factors of Drug
=> Bioactivation and Tissue Toxicity

Chapter 6: Excretion of Drugs

=> Excretion of Drugs
=> Renal Excretion of Drugs
=> Concept of Clearance
=> Factors Affecting Renal Excretion or Renal Clearance
=> Renal Function and Renal Failure
=> Non-Renal Routes of Drug Excretion

Chapter 7: Pharmacokinetic Drug Interactions

=> Pharmacokinetic Drug Interactions
=> Factors Contributing to Drug Interactions
=> Mechanisms of Pharmacokinetic Drug Interactions
=> Interactions Affecting Absorption, Distribution, Metabolism, Excretion of Drugs

Chapter 8: Pharmacokinetics Basic Considerations

=> Pharmacokinetics: Basic Considerations
=> Plasma Drug Concentration-Time Profile
=> Pharmacokinetic Parameters
=> Pharmacodynamic Parameters
=> Rate, Rate Constants and Orders of Reactions
=> Zero-Order Kinetics (Constant Rate Processes)
=> Zero-Order Half-Life
=> First-Order Kinetics (Linear Kinetics)
=> First-Order Half-Life
=> Mixed-Order Kinetics (Nonlinear Kinetics)
=> Pharmacokinetic Parameters/Variables
=> Various approaches used for quantitative study of kinetic processes

Chapter 9: Compartment Modelling

=> Compartment Modelling
=> One-Compartment Open Model (Instantaneous Distribution Model)
=> One-Compartment Open Model : Intravenous Bolus Administration
=> One-Compartment Open Model: Intravenous Infusion
=> One-Compartment Open Model: Extravascular Administration
=> Urinary Excretion Data (Disposition Viewed from Urine only)
=> Multicompartment Models (Delayed Distribution Models)
=> Two-Compartment Open Model
=> Two-Compartment Open Model: Intravenous Bolus Administration
=> Two-Compartment Open Model: Intravenous Infusion
=> Two-Compartment Open Model: Extravascular Administration - First-Order Absorption

Chapter 10: Nonlinear Pharmacokinetics

=> Nonlinear Pharmacokinetics
=> Causes of Nonlinearity
=> Michaelis Menten Equation

Chapter 11: Bioavailability and Bioequivalence

=> Bioavailability and Bioequivalence
=> Considerations In In-Vivo Bioavailability Study Design
=> Bioequivalence Studies
=> Methods For Enhancement of Bioavailability
=> Bioavailability Enhancement Through Enhancement of Drug Solubility or Dissolution Rate
=> Bioavailability Enhancement Through Enhancement of Drug Permeability Across Biomembrane
=> Bioavailability Enhancement Through Enhancement of Drug Stability
=> Bioavailability Enhancement Through Gastrointestinal Retention
=> Applications of Pharmacokinetic Principles
=> Design of Dosage Regimens
=> Individualization
=> Monitoring Drug Therapy

Chapter 12: Drug Concentration and Pharmacological Response

=> Drug Concentration and Pharmacological Response
=> Problems in Developing PK/PD Relationship
=> Concentration-Response Relationships - Pharmacodynamic Models
=> Onset/Duration of Effect-Concentration Relationships
=> Intensity of Effect-Concentration Relationships

Chapter 13: Controlled Release Medication

=> Controlled Release Medication
=> Factors in the Design of Controlled-Release Drug Delivery Systems
=> Pharmacokinetic Principles in the Design and Fabrication of Controlled-Release Drug Delivery Systems
=> Drug Release Patterns of Controlled Delivery Dosage Forms
=> Classification of CRDDS
=> Oral Controlled Release Systems
=> Parenteral Controlled Release Systems
=> Transdermal Drug Delivery Systems
=> Ophthalmic Drug Delivery Systems
=> Intravaginal & Intrauterine Drug Delivery Systems
=> Bioavailability Testing of Controlled Release Formulations

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