Plasma Drug Concentration-Time Profile
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A direct relationship exists between the concentration of drug at the biophase (site of action) and the concentration of drug in plasma.
Plasma Drug Concentration-Time Profile
A direct relationship exists between the
concentration of drug at the biophase (site of action) and the concentration of
drug in plasma. Two categories of parameters can be evaluated from a plasma
concentration time profile –
·
Pharmacokinetic parameters, and
·
Pharmacodynamic parameters.
A typical plasma drug concentration-time curve
obtained after a single oral dose of a drug and showing various pharmacokinetic
and pharmacodynamic parameters is depicted in Fig. 8.1. Such a profile can be
obtained by measuring the concentration of drug in plasma samples taken at
various intervals of time after administration of a dosage form and plotting
the concentration of drug in plasma (Y-axis)
versus the corresponding time at which the plasma sample was collected (X-axis).
Fig. 8.1. A typical plasma
concentration-time profile showing pharmacokinetic and pharmacodynamic parameters, obtained after oral administration of
single dose of a drug.
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