The model can be depicted as shown below with elimination from the central compartment.

__Two-Compartment Open Model__

__Intravenous Infusion__

The model can be depicted as shown below with
elimination from the central compartment.

The plasma or central compartment concentration of
a drug that fits two-compartment model when administered as constant rate
(zero-order) i.v. infusion, is given by equation:

At steady-state (i.e. at time infinity), the second
and the third term in the bracket becomes zero and the equation reduces to:

Now V_{c}K_{E} = V_{d}ß.
Substituting this in equation 9.113, we get:

The loading dose X_{o,L} to obtain C_{ss}
immediately at the start of infusion can be calculated from equation:

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