Miscellaneous Conjugation Reactions

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Chapter: Biopharmaceutics and Pharmacokinetics : Biotransformation of Drugs

Some of the rare conjugation reactions are mentioned below.


MISCELLANEOUS CONJUGATION REACTIONS

Some of the rare conjugation reactions are mentioned below.

Conjugation of Cyanide

The toxicity of cyanide ion is due to its ability to arrest enzymes involved in cellular respiration and convert haemoglobin to cyanomethemoglobin which lacks the ability to transport oxygen to tissues. Conjugation of cyanide ion involves transfer of sulphur atom from thiosulphate to the cyanide ion in presence of enzyme rhodanese to form inactive thiocyanate.


Conjugation with Ribose

Endogenous purine and pyrimidine bases conjugate with ribose to form nucleotides.

Conjugation with Taurine

Taurine, a β-amino sulphonic acid, conjugates the endogenous bile acids to produce components of bile.

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