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Chapter: Medicinal Chemistry : Analgesics, Antipyretics, and NSAIDs

i. Nabumetone (Nabuflam, Niltis) ii. Nimesulide iii. Analgin - Synthesis and Drug Profile



i. Nabumetone (Nabuflam, Niltis)

Properties and uses: Nabumetone is a white crystalline powder, practically insoluble in water, freely soluble in acetone, and slightly soluble in methanol. It is a nonacidic compound and because of this nature, it produces minimum gastrointestinal side effect. It is indicated in the treatment of acute and chronic treatment of osteoarthritis and rheumatoid arthritis.


Dose: For pain and inflammation associated with osteoarthritis and rheumatoid arthritis adult dose is 1 g as a single dose in the evening followed by 0.5–1 g in the morning.

Dosage forms: Nabumetone oral suspension B.P., Nabumetone tablets B.P.

Assay: It is assayed by adopting liquid chromatography technique.


ii. Nimesulide


Properties and uses: Nimesulide is a yellowish crystalline powder, practically insoluble in water, soluble in acetone, and slightly soluble in anhydrous ethanol. It contains a sulphonamide moiety as an acidic group rather than a carbonic acid. It shows moderate incidence of gastric side effects because it exhibits significant selectivity towards COX-2, used as analgesic and anti-inflammatory agent.


iii. Analgin


Uses: Used as an analgesic and anti-inflammatory agent.


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