Regulation of the Cycle

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Chapter: Biochemistry : Tricarboxylic Acid Cycle and Pyruvate Dehydrogenase Complex

In contrast to glycolysis, which is regulated primarily by PFK-1, the TCA cycle is controlled by the regulation of several enzymes.


REGULATION OF THE CYCLE

In contrast to glycolysis, which is regulated primarily by PFK-1, the TCA cycle is controlled by the regulation of several enzymes (see Figure 9.8). The most important of these regulated enzymes are those that catalyze reactions with highly negative ∆G0: citrate synthase, isocitrate dehydrogenase, and α-ketoglutarate dehydrogenase complex. Reducing equivalents needed for oxidative phosphorylation are generated by the PDH complex and the TCA cycle, and both processes are upregulated in response to a decrease in the ratio of ATP to ADP.

Figure 9.8 A. [Note: GTP and ATP are interconverted by nucleoside diphosphate kinase.] Production of reduced coenzymes, ATP, and CO2 in the citric acid cycle. B. Inhibitors and activators of the cycle.

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