Regulation of the Cycle
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In contrast to glycolysis, which is regulated primarily by PFK-1, the TCA cycle is controlled by the regulation of several enzymes.
REGULATION OF THE CYCLE
In contrast to
glycolysis, which is regulated primarily by PFK-1, the TCA cycle is controlled
by the regulation of several enzymes (see Figure 9.8). The most important of
these regulated enzymes are those that catalyze reactions with highly negative
∆G0: citrate synthase, isocitrate dehydrogenase, and α-ketoglutarate
dehydrogenase complex. Reducing equivalents needed for oxidative
phosphorylation are generated by the PDH complex and the TCA cycle, and both
processes are upregulated in response to a decrease in the ratio of ATP to ADP.
Figure 9.8 A. [Note: GTP and ATP are interconverted by nucleoside diphosphate kinase.] Production of reduced coenzymes, ATP, and CO2 in the citric acid cycle. B. Inhibitors and activators of the cycle.
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