The kidney is particularly vulnerable to adverse drug reactions (ADRs).
Renal Adverse Drug
Reactions
The
kidney is particularly vulnerable to adverse drug reactions (ADRs) (Porter,
Palmer and Henrich, 2003). Because it excretes many of their metabolites, it is
exposed to high concentrations of these drugs. More-over, several renal
transport processes potentially lead to accumulation of drugs in renal cells. A
constant abundant oxygen supply to renal tissue is required to support active
ion and solute transport, making it particularly vulnerable to any change in
blood flow and oxygen deprivation. The thick ascending limb of Henleās loop is
the principal site of NaCl reabsorption and additionally is suffering from a
marginal blood supply via the vasa recta. Any drug that interferes with renal
blood flow at this site may induce acute tubular necrosis which can lead to
acute renal failure (ARF).
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